Search results for CHK1

Serine/threonine-Protein Kinase Chk1 (CHK1) Antibody, Abbexa, abx012849

Rabbit polyclonal antibody against CHK1 protein. Immunogen region is Internal.

Serine/threonine-Protein Kinase Chk1 (CHK1) Antibody, Abbexa, abx031571

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Serine/threonine-Protein Kinase Chk1 (CHK1) Antibody, Abbexa, abx025544

CHK1 Antibody is a Mouse Monoclonal antibody against CHK1.

CHK1 (pS317) Antibody, Abbexa, abx031852

Checkpoint pathways control the order and timing of cell cycle transitions and ensure that critical events, such as DNA replication and chromosome segregation, are completed with high fidelity. The S. pombe Chk1 gene encodes a protein kinase that is required for the DNA damage checkpoint. Antibodies against CHK1 recognized a 54-kD protein on immunoblots of mammalian cell extracts. However, CHK1 is modified in response to DNA damage. In vitro, CHK1 directly phosphorylated a regulator of CDC2 tyrosine phosphorylation, CDC25C. In response to DNA damage, CHK1 phosphorylates and inhibits CDC25C, thus preventing activation of the CDC2-cyclin B complex and mitotic entry. CHK1 directly phosphorylates CDC25A during an unperturbed cell cycle, and that phosphorylation of CDC25A by CHK1 is required for cells to delay cell cycle progression in response to double-strand DNA breaks.

Chk1 Antibody (YA505), MedChemexpress, HY-P80082

Chk1 Antibody (YA505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Chk1.

Chk1 Antibody (YA3505), MedChemexpress, HY-P83808

Chk1 Antibody (YA3505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Chk1.

CHK1 Primary Antibody, ProMab, 20031

CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

Anti-Chk1 antibody, Abcam, AB17191

Anti-Chk1 antibody, Abcam, AB47574

Cell Cycle/Checkpoint Antibody Sampler Kit#9917, Cell Signaling Technology (CST), 9917