Search results for FH

LDLR Antibody (YA3452), MedChemexpress, HY-P83717

LDLR Antibody (YA3452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LDLR.

Fumarase (D9C5) Rabbit Monoclonal Antibody#4567, Cell Signaling Technology (CST), 4567

Fumarase (D9C5) Rabbit Monoclonal Antibody recognizes endogenous levels of total fumarase protein.

Fumarase (F4J2L) Rabbit Monoclonal Antibody#55242, Cell Signaling Technology (CST), 55242

Fumarase (F4J2L) Rabbit Monoclonal Antibody recognizes endogenous levels of total fumarase protein.

LDL Receptor (LDLR) Rabbit mAb, ABclonal, A20808

Factor H antibody, Internal, Genetex, GTX89512

LDL Receptor antibody, Internal, Genetex, GTX80914

LDL Receptor antibody, Genetex, GTX85109

Factor H antibody [OX-23], Genetex, GTX41629

Factor H antibody [10-10], Genetex, GTX41630

FH/FHR-1, Human, ELISA kit, Hycult Biotech, HK342

Complement Factor H (CFH) is key in the complement system, vital for immune defense and inflammation control. With a robust presence in the bloodstream at 400-800 µg/ml, CFH stabilizes complement activity, targeting immune responses. It binds C3b, speeding up alternative pathway C3-convertase breakdown and aiding C3b deactivation, thereby shielding the body from undue tissue damage. CFH’s structure, a 150 kDa glycoprotein with 20 consensus repeats, is crucial for its function. These repeats have sites essential for CFH’s anti-inflammatory role and CRP interaction, affecting cell signaling. CFH’s N-terminal and C-terminal domains, notably SCR 7, are key in fluid regulation and cellular defense. The link between CFH gene variations and a spectrum of human diseases, including kidney disorders like atypical Hemolytic Uremic Syndrome (aHUS) and vision-threatening conditions like age-related macular degeneration (AMD), underscore its clinical relevance and the potential for targeted CFH-based therapies.