Search results for MCP

MCP-1, Human, mAb MNA1, Hycult Biotech, HM2011

Monoclonal antibody MNA.1 (formerly known as 5D3-F7) recognizes human natural and recombinant monocyte chemotactic protein-1 (MCP-1). Monocyte chemotactic protein-1 (MCP-1) is a 11 kDa protein belonging to the CC subgroup of the chemokine superfamily, which stimulate the migration of monocytic cells. In contrast, the CXC chemokines predominantly activate polymorphonuclear leukocytes. The coordinated synthesis and release of MCP-1 plays a central role in both acute and chronic inflammatory processes by controlling the influx of phagocytic cells. Furthermore, their state of activation is in concert with primary inflammatory cytokines, such as IL-1, TNF-a, and IL-6. A selective accumulation of MCP-1 in the cerebrospinal fluid (CSF) of AIDS patients with cytomegalovirus encephalitis, but not with other opportunistic infections or primary lymphomas of the central nervous system , has been described. Furthermore, the chemotactic activity of MCP-1 on monocytic cells has been suggested to play a role in psoriasis, rheumatoid arthritis and atherosclerosis. No cross-reactivity of mAb MNA.1 with other cytokines has been detected.

MCP-1/CCL2 Polyclonal antibody, Proteintech, 29547-1-AP

29547-1-AP targets MCP-1/CCL2 in WB, IF, ELISA applications and shows reactivity with human samples.

MCP-1/CCL2 Polyclonal antibody, Proteintech, 26161-1-AP

26161-1-AP targets MCP-1/CCL2 in WB, IHC, IF, FC (Intra), ELISA applications and shows reactivity with mouse samples.

MCP-1/CCL2 Polyclonal antibody, Proteintech, 31520-1-AP

31520-1-AP targets MCP-1/CCL2 in WB, IHC, ELISA applications and shows reactivity with mouse, rat samples.

MCP-1 antibody (B-Z21), Covalab, Ref 00037155

MCP-1 antibody (B-K41), Covalab, Ref 00037154

MCP-1, Mouse, mAb ECE.2, Hycult Biotech, HM1019

The monoclonal antibody ECE.2 recognizes mouse monocyte chemoattractant protein 1 (MCP-1). The murine JE gene encodes the monocyte-specific cytokine monocyte chemotactic protein 1 (MCP- 1). MCP-1 is a CC chemokine of 76 amino acids (~11 kDa) and is chemotactic for monocytes and basophils but not neutrophils and eosinophils. MCP-1 is expressed by smooth muscle cells (SMC), macrophages, endothelial cells, keratinocytes and fibroblasts in response to inflammatory stimuli such as interleukin 1β and tumor necrosis factor α. MCP-1 has been implicated in a variety of inflammatory processes, including inflammatory bowel disease, rheumatoid arthritis, asthma, nephritis, and parasitic and viral infections. MCP-1 antigen is not detected in the endothelium or SMC of normal arteries. MCP-1 has also been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer) MCP-1 signals via the CCR2 receptor, and is critical for aneurysm formation because of its stability to recruit leukocytes. These leukocytes produce extracellular matrix-degrading MMPs, thereby inductin aortic remodelling and dilatation. Interleukin-6 is also involved in this amplification loop accelerating vascular inflammation. MCP-/- mice display significantly delayed wound re-epithelialization, and also delayed wound angiogenesis.

CCL8/MCP-2 Rabbit pAb- ABclonal, ABclonal, A24871

CCL12/MCP-5 Recombinant monoclonal antibody, Proteintech, 86565-1-RR

86565-1-RR targets CCL12/MCP-5 in WB, IF/ICC, ELISA applications and shows reactivity with mouse samples.

Membrane Cofactor Protein (MCP / CD46) Antibody, Abbexa, abx102461

Polyclonal Antibody to Membrane Cofactor Protein (MCP / CD46).