Search results for Thrombomodulin
Thrombomodulin (THBD) Antibody, Abbexa, abx170751
Human Thrombomodulin (THBD) Antibody is a Mouse monoclonal against Thrombomodulin (THBD).
Host
Mouse
Reactivity
Human
Applications
WB
Conjugation
Unconjugated
Thrombomodulin (THBD) Antibody, Abbexa, abx170752
Human Thrombomodulin (THBD) Antibody is a Mouse monoclonal against Thrombomodulin (THBD).
Host
Mouse
Reactivity
Human
Applications
WB
Conjugation
Unconjugated
Purified anti-CD141 Thrombomodulin Antibody anti-CD141 (Thrombomodulin) - Phx-01, BioLegend, 902102
This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA.*Predicted MW = 60 kDPositive control tissue: human placentaThis antibody reacts with an epitope within the EGF 5 domain and inhibits thrombin binding.
Host
Mouse
Reactivity
Human
Applications
IHC-F -Quality testedWB, ELISA -Verified
Conjugation
Purified anti-CD141 Thrombomodulin Antibody anti-CD141 (Thrombomodulin) - Phx-01, BioLegend, 902101
This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA.*Predicted MW = 60 kDPositive control tissue: human placentaThis antibody reacts with an epitope within the EGF 5 domain and inhibits thrombin binding.
Host
Mouse
Reactivity
Human
Applications
IHC-F -Quality testedWB, ELISA -Verified
Conjugation
Thrombomodulin, Human, mAb RTM96, Hycult Biotech, HM2146
Monoclonal antibody RTM96 recognizes thrombomodulin (a C-type lectin also known as CD141), a complex molecule located on the endothelium and a key feature in the protein C pathway. The protein C anticoagulant pathway serves as a major system for controlling coagulation and limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR), protein C and protein S. Thrombomodulin binds thrombin, directly inhibiting its clotting and cell activation potential while at the same time augmenting protein C. The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-TM complex more than 10-fold. TM also accelerates thrombin activation of a plasma procarboxypeptidase B, named thrombin activatable fibrinolysis inhibitor or TAFI resulting in slowing clot lysis. The inhibited thrombin rapidly dissociates from thrombomodulin, regenerating the anticoagulant surface. Thrombomodulin also has direct anti-inflammatory activity, minimizing cytokine formation in the endothelium and decreasing leukocyte-endothelial cell adhesion. Thrombomodulin inhibits leukocyte binding to activated endothelium. TM has been detected in a variety of cells and tissues in adults and during development, including astrocytes in the brain, keratinocytes, endothelial cells, mesothelial cells of the peritoneum, and circulating neutrophils, monocytes, and platelets. During fetal development, TM plays a central role in controlling the growth and survival of trophoblast cells in the placenta, a function essential for the maintenance of pregnancy. Thrombin binding to thrombomodulin involves anion binding exosite 1 on thrombin and epidermal growth factor (EGF) domains 4 to 6 on thrombomodulin. The monoclonal antibody RTM96 reacts with the EGF4 domain, thereby inhibiting the biological activity of thrombomodulin.
Host
Human
Reactivity
Applications
Conjugation
Thrombomodulin, Human, mAb RTM98, Hycult Biotech, HM2147
Monoclonal antibody RTM96 recognizes thrombomodulin (a C-type lectin also known as CD141), a complex molecule located on the endothelium and a key feature in the protein C pathway. The protein C anticoagulant pathway serves as a major system for controlling coagulation and limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR), protein C and protein S. Thrombomodulin binds thrombin, directly inhibiting its clotting and cell activation potential while at the same time augmenting protein C. The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-TM complex more than 10-fold. TM also accelerates thrombin activation of a plasma procarboxypeptidase B, named thrombin activatable fibrinolysis inhibitor or TAFI resulting in slowing clot lysis. The inhibited thrombin rapidly dissociates from thrombomodulin, regenerating the anticoagulant surface. Thrombomodulin also has direct anti-inflammatory activity, minimizing cytokine formation in the endothelium and decreasing leukocyte-endothelial cell adhesion. Thrombomodulin inhibits leukocyte binding to activated endothelium. TM has been detected in a variety of cells and tissues in adults and during development, including astrocytes in the brain, keratinocytes, endothelial cells, mesothelial cells of the peritoneum, and circulating neutrophils, monocytes, and platelets. During fetal development, TM plays a central role in controlling the growth and survival of trophoblast cells in the placenta, a function essential for the maintenance of pregnancy. Thrombin binding to thrombomodulin involves anion binding exosite 1 on thrombin and epidermal growth factor (EGF) domains 4 to 6 on thrombomodulin The monoclonal antibody RTM98 reacts with the EGF6 domain.
Host
Human
Reactivity
Applications
Conjugation
Thrombomodulin (THBD) Antibody (APC), Abbexa, abx274821
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Thrombomodulin (THBD) Antibody is a Guinea pig Monoclonal against Human THBD, conjugated to APC.
Host
Guinea pig
Reactivity
Human
Applications
FCM
Conjugation
APC
Thrombomodulin (THBD) Antibody (APC), Abbexa, abx347261
Thrombomodulin (THBD) Antibody (APC) is a APC-conjugated Mouse monoclonal antibody for Thrombomodulin (THBD).
Host
Mouse
Reactivity
Human
Applications
FCM
Conjugation
APC
Thrombomodulin (THBD) Antibody (Biotin), Abbexa, abx273177
Thrombomodulin (TM) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Thrombomodulin (TM).
Host
Rabbit
Reactivity
Rat
Applications
WB, IHC, IF/ICC
Conjugation
Biotin
Thrombomodulin (THBD) Antibody (PE), Abbexa, abx347265
Thrombomodulin (THBD) Antibody (PE) is a PE-conjugated Mouse monoclonal antibody for Thrombomodulin (THBD).
Host
Mouse
Reactivity
Human
Applications
FCM
Conjugation
PE
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