Search results for calreticulin

Anti-Calreticulin antibody, Abcam, AB223614

Anti-Calreticulin antibody, Abcam, AB227444

Anti-Calreticulin antibody, Abcam, AB265598

Anti-Calreticulin antibody, Abcam, AB2908

Anti-Calreticulin antibody, Abcam, AB94935

Calreticulin (CALR) Antibody, Abbexa, abx000989

CALR Antibody is a Rabbit Polyclonal antibody against CALR. Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Calreticulin (CALR) Antibody, Abbexa, abx403533

Rat Calreticulin (CALR) Antibody is a Mouse monoclonal against Calreticulin (CALR).

Calreticulin (CALR) Antibody, Abbexa, abx241024

CALR Antibody is a Rabbit Polyclonal against CALR.

Calreticulin (CALR) Antibody, Abbexa, abx129558

Calreticulin Antibody is a Rabbit Polyclonal against Calreticulin.

Calreticulin (CALR) Antibody, Abbexa, abx171534

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Calreticulin (CALR) Antibody is a Mouse Monoclonal antibody against Calreticulin (CALR).