Search results for cyclin D1

Cyclin D1 (CCND1) Antibody, Abbexa, abx100481

Polyclonal Antibody to Cyclin D1 (CCND1).

Cyclin D1 (CCND1) Antibody, Abbexa, abx031337

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Anti-Cyclin D1 FITC, DB Biotech, DB 1014

Cyclin D1 antibody (CD1.1), Covalab, Ref 00113493

Cyclin D1 (CCND1) Antibody, Abbexa, abx232124

Cyclin D1 Antibody is a Mouse Monoclonal against Cyclin D1.

Cyclin D1 (CCND1) Antibody, Abbexa, abx109797

G1/S-specific cyclin-D1 Antibody is a Rabbit Polyclonal antibody against G1/S-specific cyclin-D1.

cyclin D1 (CCND1) Antibody, Abbexa, abx432565

cyclin D1 Antibody is a Goat Polyclonal antibody against cyclin D1.

Cyclin D1 (CCND1) Antibody, Abbexa, abx214742

CCND1 Antibody is a Rabbit Polyclonal against CCND1.

Anti-Cyclin D1 antibody, Abcam, AB226977

Cyclin D1 (CCND1) Antibody, Abbexa, abx034749

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.