Search results for kinase 2.

Checkpoint Kinase 2 (CHEK2) Antibody, Abbexa, abx032373

CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.

Sphingosine Kinase 2 (SPHK2) Antibody, Abbexa, abx033255

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Pantothenate Kinase 2 (PANK2) Antibody, Abbexa, abx318220

PANK2 Antibody is a Rabbit Polyclonal against PANK2.

Adenylate kinase 2 antibody [AT7E7], Genetex, GTX57648

Ethanolamine Kinase 2 (ETNK2) Antibody, Abbexa, abx036338

Rabbit Polyclonal against the ETNK2 protein.

Tyrosine Kinase 2 (TYK2) Antibody, Abbexa, abx129402

Tyrosine Kinase 2 Antibody is a Rabbit Polyclonal against Tyrosine Kinase 2.

Adenylate Kinase 2 (AK2) Antibody, Abbexa, abx230245

AK2 Antibody is a Mouse Monoclonal against AK2.

Sphingosine Kinase 2 (SPHK2) Antibody, Abbexa, abx115783

Sphingosine Kinase 2 Antibody is a Rabbit Polyclonal antibody against Sphingosine Kinase 2.

Adenylate Kinase 2 (AK2) Antibody, Abbexa, abx037426

Rabbit Polyclonal against the AK2 protein.

Tyrosine Kinase 2 (TYK2) Antibody, Abbexa, abx001740

TYK2 Antibody is a Rabbit Polyclonal antibody against TYK2. This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.