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Human Calreticulin (CALR) ELISA Kit, Abbexa, abx150912

Human Calreticulin (CALR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Calreticulin concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Calreticulin (CALR)No significant cross-reactivity or interference between Calreticulin (CALR) and analogues was observed.

Calreticulin (CALR) Antibody (FITC), Abbexa, abx306420

CALR Antibody (FITC) is a Rabbit Polyclonal against CALR conjugated to FITC.

Calreticulin (CALR) Antibody, Abbexa, abx349860

Calreticulin (CALR) Antibody is a Recombinant Mouse Monoclonal antibody for the detection of Human, Mouse CALR.

[KO Validated] Calreticulin Rabbit mAb, ABclonal, A20986

Calreticulin (CALR) Antibody (Biotin), Abbexa, abx445321

Calreticulin Antibody (Biotin) is a Rabbit Polyclonal against Calreticulin.

Calreticulin (CALR) Antibody, Abbexa, abx100742

Polyclonal Antibody to Calreticulin (CALR).

Calreticulin antibody, Internal, Genetex, GTX81663

Calreticulin antibody [1G6A7], Genetex, GTX83089

Calreticulin antibody, Genetex, GTX83093

Calreticulin (CALR) Antibody, Abbexa, abx010484

Calreticulin is a multifunctional protein that acts as a major Ca (2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.