Search results for BTK

BTK (pY551) Antibody, Abbexa, abx119222

BTK (pY551) Antibody is a Rabbit Polyclonal antibody against BTK (pY551).

BTK antibody [10E10], Genetex, GTX84785

BTK antibody [3A2], Genetex, GTX84789

BTK antibody [12H4], Genetex, GTX84792

BTK Primary Antibody, ProMab, 20132

Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

Tyrosine-Protein Kinase BTK Phospho-Tyr223 (BTK pY223) Antibody, Abbexa, abx010635

Tyrosine-Protein Kinase BTK Phospho-Tyr223 (BTK pY223) Antibody is a Rabbit Polyclonal antibody for the detection of Phospho-BTK (Tyr 223). Defects in the Bruton tyrosine kinase (BTK) gene cause Agammaglobulinemia. Agammaglobulinemia is an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement.

Tyrosine-Protein Kinase BTk Phospho-Tyr223 (BTK pY223) Antibody, Abbexa, abx012418

Rabbit polyclonal antibody against BTK protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:Y223, M:Y223, R:Y224.

B Cell Signaling Antibody Sampler Kit#9768, Cell Signaling Technology (CST), 9768

Anti-BTK Antibody (R2C81), AntibodySystem, RHG07801

Halotyrosine, mAb BTK-94C, Hycult Biotech, HM5016

Halotyrosine, clone BTK-94C is recommended for detection of bromotyrosine modified proteins. Halogenation is a chemical reaction that substitutes a molecule’s hydrogen atom with halogen, a nonmetal element. Fluorination, chlorination, bromination and iodination are the four types of halogenation. Halogenated organic compounds are found as natural products in many living organisms. Halotyrosine residues are the result of tyrosine modification, usually bromine or chlorine. This generally occurs as a result of immune cell actions or oxidative stress. For example, activated eosinophils release eosinophil peroxidase, which in turn produces hypobromite (HOBr). Hypobromite can then react with proteins to create bromotyrosine residues. Studies on total bromotyrosine levels have shown that these protein modifications are increased in asthmatics, but are decreased in response to anti-inflammatory drugs.