Search results for Cellular tumor antigen p53
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx448535
p53 Antibody is a Rabbit Polyclonal against p53.
Host
Rabbit
Reactivity
Human
Applications
WB, IF/ICC
Conjugation
Unconjugated
Cellular Tumor Antigen P53 (TP53) Antibody, Abbexa, abx422672
Cellular Tumor Antigen P53 (TP53) Antibody is a Mouse monoclonal against Cellular Tumor Antigen P53 (TP53).
Host
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx034682
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx227036
Cellular Tumor Antigen p53 (TP53) Antibody is a Rabbit Monoclonal antibody for the detection of p53.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC, IP
Conjugation
Unconjugated
Cellular Tumor Antigen P53 (TP53) Antibody, Abbexa, abx422669
Cellular Tumor Antigen P53 (TP53) Antibody is a Rabbit monoclonal against Cellular Tumor Antigen P53 (TP53).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF/ICC, IP
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx327634
TP53 Antibody is a Rabbit Polyclonal against TP53.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx032762
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx329862
TP53 Antibody is a Rabbit Polyclonal against TP53.
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
ELISA, WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx236084
P53 Antibody is a Mouse Monoclonal against P53.
Host
Mouse
Reactivity
Human, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Cellular Tumor Antigen p53 (TP53) Antibody, Abbexa, abx004447
TP53 Antibody is a Rabbit Polyclonal antibody against TP53. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC, IP
Conjugation
Unconjugated
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