Search results for FH
FH & FHRs, Human, mAb L20/3, Hycult Biotech, HM2249
Monoclonal antibody L20/3 recognizes human complement FH &FHRs. This is the first regulatory protein of the alternative pathway of the complement system. There are three pathways of complement activation. The classical pathway is initiated by immune complexes; the alternative pathway which does not require an antibody-antigen interaction for its activation; and the lectin pathway by surface bound mannan binding lectin. Each generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. The complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. CFH binds to C3b, accelerates the decay of the alternative pathway C3-convertase (C3bBb) and acts as co-factor for the factor I-mediated proteolytic inactivation of C3b. Human complement factor H is a single-chain serum glycoprotein of 150 kD with a modular structure consisting of a tandem of 20 homologous units of about 60 amino acid, called short consensus repeats (SCR). Numerous functional sites have been identified along the 20 SCR domain structure of factor H. Three C3-binding sites have been identified in SCR1-4, SCR6-10 and SCR13-20 respectively. Three polyanion binding sites like heparin and several glycoaminoglycans have also been identified in the SCR7, 13 and 20. CFH displays an anti-inflammatory function and acts as a ligand for CRP. CFH has two important functional domains that are located at the opposite ends of the protein. The N-terminal fragment of the factor H molecule is an essential fluid phase regulator of the alternative pathway. With the C-terminal domain and SCR7, CFH binds to cell and tissue surface. This mediates its protective role also on host cell surface. CFH is a relatively abundant plasma protein, with a concentration of 0.4-0.8 mg/ml, that is essential to maintain complement homeostasis and to restrict the action of complement to activating surfaces. CFH regulates complement activation both in fluid phase and on cellular surfaces. Genetic analyses reveal a clear association of CFH with different human diseases. These include diseases of the kidney, the atypical form of Hemolytic Uremic Syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). Furthermore, CFH is associated with age-related macular degeneration (AMD), a disease of the eye.
Host
Human
Reactivity
Applications
Conjugation
Rat Fumarate Hydratase (FH) ELISA Kit, Abbexa, abx518867
Rat Fumarate Hydratase (FH) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Fumarate hydratase, mitochondrial concentrations in tissue homogenates, cell lysates and other biological fluids.
Host
Reactivity
Rat
Applications
ELISA
Conjugation
Mouse Fumarate Hydratase (FH) ELISA Kit, Abbexa, abx518865
Mouse Fumarate Hydratase (FH) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Fumarate hydratase, mitochondrial concentrations in tissue homogenates, cell lysates and other biological fluids.
Host
Reactivity
Mouse
Applications
ELISA
Conjugation
Pig Fumarate Hydratase (FH) ELISA Kit, Abbexa, abx518866
Pig Fumarate Hydratase (FH) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Pig Fumarate hydratase, mitochondrial concentrations in tissue homogenates, cell lysates and other biological fluids.
Host
Reactivity
Pig
Applications
ELISA
Conjugation
![Anti-Collagen III antibody [FH-7A] Brand Logo](https://file.buyantibody.com/public/brand/20260608/Abcam.jpg "Click to View Anti-Collagen III antibody [FH-7A] Product Detail")
Anti-Collagen III antibody [FH-7A], Abcam, AB6310
Anti-Collagen III antibody [FH-7A] (ab6310) is a House Mouse Monoclonal antibody and is validated for use in Dot, ELISA, ICC/IF, IHC-Fr, IHC-P, WB in human samples. Anti-Collagen III antibody [FH-7A] (ab6310) has been cited over 172 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality validation processes ensure Anti-Collagen III antibody [FH-7A] (ab6310) has high sensitivity and specificity. Anti-Collagen III antibody [FH-7A] (ab6310) has 13 independent reviews from customers. Anti-Collagen III antibody [FH-7A] (ab6310) specifically detects Collagen III (UniProt ID: P02461; Molecular weight: 95kDa) and is sold in 50 uL selling sizes. Collagen III is a critical fibrillar collagen that plays a significant role in the structural integrity of various tissues, including the skin, lungs, and blood vessels. Alterations in Collagen III expression are associated with several diseases. For instance, mutations in the COL3A1 gene, which encodes Collagen III, can lead to Ehlers-Danlos syndrome type IV, a condition characterized by fragile blood vessels and organs. Additionally, abnormal Collagen III deposition is implicated in fibrotic diseases, such as liver cirrhosis and pulmonary fibrosis, where excessive collagen accumulation disrupts normal tissue architecture. Understanding Collagen III's role in these diseases is crucial for developing targeted therapies and improving patient outcomes. Type III collagen, [a1(III)]3 ,is an approx. 300 kDa molecule, found predominantly in skin, blood vessels, liver, placenta, tongue, and thymus. Collagen type III forms cofibrils with type I and/or V collagens in a number of tissues of mesenchymal origin, such as skin, tendon, ligaments, and bone. This collagen type is involved, directly or indirectly in several genetic diseases, including Ehlers-Danlos type IV disease. This product was changed from ascites to tissue culture supernatant on 17 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
Host
Mouse
Reactivity
Rat, Human
Applications
ELISA, Dot, WB, ICC/IF, IHC-P, IHC-Fr
Conjugation
Human Fumarate Hydratase (FH) ELISA Kit, Abbexa, abx251329
Human Fumarate Hydratase (FH) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Fumarate hydratase, mitochondrial concentrations in tissue homogenates, cell lysates and other biological fluids.
Host
Reactivity
Human
Applications
ELISA
Conjugation
Anti-FH/Fumarase antibody [EPR11648] - BSA and Azide free, Abcam, AB249667
ab249667 is the carrier-free version of ab171948 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human
Applications
WB, ICC/IF
Conjugation
Anti-FH/Fumarase antibody [EPR21104] - BSA and Azide free, Abcam, AB234905
ab234905 is the carrier-free version of ab233394 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Mouse, Rat, Human
Applications
Flow Cyt (Intra), IP, WB, IHC-P, ICC/IF
Conjugation
Anti-FH/Fumarase antibody [EPR21105] - BSA and Azide free, Abcam, AB234907
ab234907 is the carrier-free version of ab233393 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Mouse, Rat, Human
Applications
Flow Cyt (Intra), IP, ICC/IF, IHC-P, WB
Conjugation
Alexa Fluor® 488 Anti-FH/Fumarase antibody [EPR21104], Abcam, AB320700
Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
Host
Rabbit
Reactivity
Human, Mouse, Rat, Human, Mouse, Rat
Applications
Flow Cyt (Intra), ICC/IF, IHC-P
Conjugation
Alexa Fluor® 488
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