Search results for HMGB1 antibody

High Mobility Group Box 1 (HMGB1) antibody, Covalab, Ref 00030642

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx242218

HMGB1 Antibody is a Rabbit Polyclonal against HMGB1.

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx001990

HMGB1 Antibody is a Rabbit Polyclonal antibody against HMGB1. High mobility group protein B1 (HMGB1) belongs to a family of highly conserved proteins that contain HMG box domains (1,2). All three family members (HMGB1, HMGB2, and HMGB3) contain two HMG box domains and a C-terminal acidic domain. HMGB1 is a widely expressed and highly abundant protein (2). HMGB2 is widely expressed during embryonic development, but is restricted to lymphoid organs and testis in adult animals (3). HMGB3 is only expressed during embryogenesis (4). While expression varies, the biochemical properties of the different family members may be indistinguishable. The HMG box domains facilitate the binding of HMGB proteins to the minor groove of DNA, which results in local bending of the DNA double helix (1,2). HMGB proteins are recruited by and help facilitate the assembly of site-specific DNA binding proteins to their cognate binding sites in chromatin. For example, HMGB1 facilitates the binding of Hox proteins, Oct-1, p53, Rel proteins, and steroid hormone receptor proteins to their target gene promoters (1,2). In addition to their functions in the nucleus, HMGB proteins play a significant role in extracellular signaling associated with inflammation (5,6). HMGB1 is massively released into the extracellular environment during cell necrosis, but not apoptosis. Extracellular HMGB1 "alarms" the innate immune system by acting as a chemoattractant for inflammatory leukocytes, smooth muscle cells, and stem cells, functioning as an immune adjuvant for soluble and particulate antigens, and triggering activation of T cells and dendritic cells. In addition, activated monocytes, macrophages and, dendritic cells also secrete HMGB1, forming a positive feedback loop that results in the release of additional cytokines and neutrophils. Hypoxia has also been shown to cause the release of HMGB1 in the liver, and some studies suggest a role for extracellular HMGB1 in tumor homeostasis (5,6).

High mobility group protein B1 (Hmgb1) Antibody, Abbexa, abx343502

High mobility group protein B1 (Hmgb1) Antibody is a Rabbit Polyclonal antibody for the detection of Rat Hmgb1.

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx103012

Polyclonal Antibody to HMGB1.

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx318228

HMGB1 Antibody is a Rabbit Polyclonal against HMGB1.

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx028080

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V (D) J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).

High mobility group protein B1 (HMGB1) Antibody, Abbexa, abx457756

High mobility group protein B1 (HMGB1) Antibody is a monoclonal Mouse antibody for the detection of HMGB1.

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx110490

HMGB1 Antibody is a Rabbit Polyclonal antibody against HMGB1.

High Mobility Group Protein B1 (HMGB1) Antibody, Abbexa, abx233924

HMGB1 Antibody is a Rabbit Polyclonal against HMGB1.