Search results for LCK

Lck antibody [N1C1], Genetex, GTX107432

Lck antibody [N3C3], Genetex, GTX107785

LCK (pY505) Antibody, Abbexa, abx000336

LCK (pY505) Antibody is a Rabbit Polyclonal antibody against LCK (pY505). This gene is a member of the Src family of protein tyrosine kinases (pYKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.

Lck (pY505) Antibody, Abbexa, abx119239

Lck (pY505) Antibody is a Rabbit Polyclonal antibody against Lck (pY505).

Anti-Lck antibody, Abcam, AB189933

Lck Antibody (YA3667), MedChemexpress, HY-P83970

Lck Antibody (YA3667) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Lck.

Mouse Lck Antibody, Abbexa, abx027836

Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor (TCR) linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR (By similarity).

p56lck / LCK antibody, Covalab, Ref 00107323

Lck Primary Antibody, ProMab, 20083

Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.

Proto-oncogene tyrosine-protein kinase LCK (LCK) Antibody (Biotin), Abbexa, abx106038

Tyrosine-protein kinase Lck Antibody (Biotin) is a Rabbit Polyclonal antibody against Tyrosine-protein kinase Lck conjugated to Biotin.