Search results for CDKN2A

CDKN2A/p19ARF Rabbit mAb, ABclonal, A24653

CDKN2A/P16 Primary Antibody, ProMab, 31824

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

CDKN2A / p16INK4a (phospho Ser326) antibody, Genetex, GTX32378

Tumor Suppressor ARF (CDKN2A) Antibody, Abbexa, abx013162

Rabbit polyclonal antibody against p14 ARF protein. Immunogen region is Internal.

CDKN2A Interacting Protein (CDKN2AIP) Antibody, Abbexa, abx375996

CDKN2A Interacting Protein (CDKN2AIP) Antibody is a Rabbit Polyclonal antibody against CDKN2A Interacting Protein (CDKN2AIP).

CDKN2A / p16INK4a antibody [G175-405], Genetex, GTX01783

Tumor Suppressor ARF (CDKN2A) Antibody, Abbexa, abx030864

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

Phospho-CDKN2A/p16INK4a (Ser152) Antibody, Covalab, Ref 00120223

Phospho-CDKN2A/p16INK4a (Ser152) Antibody, Covalab, Ref 00120445

CDKN2A/p16INK4a Rabbit pAb- ABclonal, ABclonal, A11337