Search results for IGF1R

IGF1R beta (phospho Tyr1250) antibody, Genetex, GTX50683

IGF1R alpha + beta antibody [alphaIR3], Genetex, GTX16890

INSR (pY1150) / IGF1R (pY1135) Antibody, Abbexa, abx000129

INSR (pY1150) / IGF1R (pY1135) Antibody is a Rabbit Polyclonal antibody against INSR (pY1150) / IGF1R (pY1135). Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.

Anti-CD221/IGF1R Antibody (R3A51), AntibodySystem, RHC29905

Anti-CD221/IGF1R Antibody (R3A52), AntibodySystem, RHC29906

Anti-CD221/IGF1R Antibody (R3A53), AntibodySystem, RHC29907

IGF1R beta (phospho Tyr1316) antibody, Genetex, GTX133448

IGF1R beta (phospho Tyr950) antibody, Genetex, GTX133449

Anti-CD221/IGF1R Antibody (R1L37), AntibodySystem, RHC29903

Anti-CD221/IGF1R Antibody (R1L38), AntibodySystem, RHC29904