Search results for calreticulin
Calreticulin (CALR) Antibody, Abbexa, abx100742
Polyclonal Antibody to Calreticulin (CALR).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Calreticulin Primary Antibody, ProMab, 20181
Calreticulin, also known as RO, CRT, SSA, cC1qR, FLJ26680, CALR. Entrez Protein NP_004334. It is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
Host
Reactivity
Applications
Conjugation
Calreticulin (CALR) Antibody, Abbexa, abx010484
Calreticulin is a multifunctional protein that acts as a major Ca (2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Unconjugated
Calreticulin (CALR) Antibody, Abbexa, abx013448
Rabbit polyclonal antibody against CALR protein. Immunogen region is N-terminal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Calreticulin (CALR) Antibody, Abbexa, abx403536
Rat Calreticulin (CALR) Antibody is a Mouse monoclonal against Calreticulin (CALR).
Host
Mouse
Reactivity
Rat
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Calreticulin (CALR) Antibody (Biotin), Abbexa, abx341389
Calreticulin (CALR) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human CALR.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Calreticulin 3 (CALR3) Antibody, Abbexa, abx231223
CALR3 Antibody is a Rabbit Polyclonal against CALR3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Calreticulin (CALR) Antibody (FITC), Abbexa, abx445322
Calreticulin Antibody (FITC) is a Rabbit Polyclonal against Calreticulin.
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Chicken, Guinea pig, Monkey, Pig, Hamster, Rabbit, Sheep
Applications
WB, IHC, IF/ICC, FCM, IP
Conjugation
FITC
Calreticulin (CALR) Antibody (Biotin), Abbexa, abx306421
CALR Antibody (Biotin) is a Rabbit Polyclonal against CALR conjugated to Biotin.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Calreticulin 3 (CALR3) Antibody, Abbexa, abx322754
CALR3 Antibody is a Rabbit Polyclonal against CALR3.
Host
Rabbit
Reactivity
Human, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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