Search results for 10
Collectin-10, Human, ELISA, Hycult Biotech, HK364
The complement system is the first line of defense against pathogens and important component of innate as well as adaptive immunity. The three major pathways of innate immunity are the classical, alternative and lectin pathway. Each pathway is activated in a different way. The lectin pathway recognizes foreign carbohydrates structures via MBL, ficolins and collectins. Collectin-10 (collectin liver 1/CL-L1), CL-K1 (collectin kidney 1/Collectin-11) and CL-P1 (collectin placenta 1/Collectin-12) are most recently discovered. Collectin-10 and Collectin-11 are quite homolog, have a classical collectin structure and are highly conserved in mammals. Collectin-10 and Collectin-11 can bind to carbohydrate ligands and DNA of pathogens or on the membrane of damaged cells. They interact with MASPs and activate in a similar way to MBL and ficolins the lectin pathway. Native Collectin-10 displays a calcium dependent binding pattern. A conformational change in carbohydrate recognition domain (CRD) is indicated when the calcium ion is removed by chelation with EDTA. Collectins share a common multimeric structure leading to varying degrees of oligomerization. The chains consist of a collagen-like region, an alpha helicon neck domain and a CRD. Collectin-10 was originally found in hepatocytes but mRNA has also been found in placenta, adrenal glands, lung, small intestine and prostate. Initially it was thought to exist only as a cytoplasmic protein. Recent studies also show presence in circulation, either separately or in heteromeric complex with Collectin-11. The average serum concentration is depending on the study, localization and health status of the population and is considered to be ~300ng/ml (range 200-500ng/ml) for healthy individuals. Collectin-10 is encoded by a gene called COLEC10 on chromosome 8. A few polymorphisms have been identified which can lead to increase (up to 40%) of the Collectin-10 serum concentration. In SLE patients Collectin-10 levels are decreased by approximately 20%. High levels of Collectin-10 are beneficial at time of kidney transplantation and is associated with increased long term overall mortality. Elevated levels have also been found in the early phase of acute liver failure and in cirrhosis. Due to (short) periods of microbial challenge fluctuations in Collectin-10 in healthy individuals are seen in a given period. In plasma higher levels of Collectin-10 are found than in serum (ca 30%).
Host
Human
Reactivity
Applications
Conjugation
IL-10, Human, pAb, Hycult Biotech, HP9016
The antibody reacts with human Interleukin-10 (IL-10) of both natural and recombinant origin. IL-10 is a pluripotent cytokine with important immunosuppressive actions: it can inhibit cytokines involved in the Th1 response such as IL-2, Interferon gamma and also inhibits the production of pro-inflammatory cytokines such as IL-1, IL-6, IL-8 and TNF-alpha. The antibody inhibits the biological activity of natural and recombinant human IL-10. The antigen specificity was further assessed by ELISA. No cross reactivities with other cytokines have been detected.
Host
Human
Reactivity
Applications
Conjugation
Septin 10 (SEPTIN10) Antibody, Abbexa, abx029892
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternate splicing results in two transcript variants encoding different isoforms.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Protocadherin-10 (PCDH10) Antibody, Abbexa, abx239871
Protocadherin-10 (PCDH10) Antibody is a Rabbit Polyclonal antibody for the detection of PCDH10. Potential calcium-dependent cell-adhesion protein.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Interleukin 10 (IL10) Antibody, Abbexa, abx034229
The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Syntaxin-10 (STX10) Antibody, Abbexa, abx238444
Syntaxin 10 Antibody is a Rabbit Polyclonal against Syntaxin 10.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Frizzled-10 (FZD10) Antibody, Abbexa, abx233219
Frizzled 10 Antibody is a Rabbit Polyclonal against Frizzled 10.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Keratin 10 (KRT10) Antibody, Abbexa, abx032944
KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in its gene are associated with epidermolytic hyperkeratosis.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Interleukin 10 (IL10) Antibody, Abbexa, abx104934
Interleukin 10 Antibody is a Rabbit Polyclonal against Interleukin 10.
Host
Rabbit
Reactivity
Horse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Interleukin 10 (IL10) Antibody, Abbexa, abx342103
Interleukin 10 (IL10) Antibody is a sheep polyclonal antibody for the detection of Interleukin 10.
Host
Sheep
Reactivity
General (All species)
Applications
ELISA
Conjugation
Unconjugated
Please provide the required information below so that we can quickly source your products.