Search results for Alpha-

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GSK3 alpha Antibody Brand Logo
ID: BAB329645127

GSK3 alpha Antibody, Abbexa, abx033883

Glycogen synthase kinase 3-alpha (GSK3A) is a multifunctional protein serine kinase implicated in the control of several regulatory proteins including glycogen synthase and transcription factors. It also plays a role in the WNT and PI3K signaling pathways.1 Under resting conditions GSK3A and its homologs are highly phosphorylated at tyr279 in the phosphorylation loop.2 Constitutive phosphorylation of this tyrosine is important for kinase activity. Dephosphorylation of tyr279 after mitogen activation is accompanied by kinase inactivation. PKA as well as PI3K-activated PKB inactivate GSK3A by phosphorylation at ser21.3 Lysophosphatidic acid primarily utilizes a PKC-dependent pathway to modulate GSK3 and certain growth factors (e.g., PDGFB), which control GSK3 mainly through PIK3-PKB, are able to regulate GSK3 through an alternative, redundant phospholipase-C-gamma-PKC pathway.4 Alzheimer disease (AD) is associated with increased production and aggregation of amyloid-beta-40 and 42 peptides into plaques. GSK3A is required for maximal production of the beta-amyloid-40 and 42 peptides generated from the amyloid precursor protein (APP) by presenilin (PSEN1) dependent gamma-secretase cleavage.5 In vitro, lithium, a GSK3A inhibitor, blocked the production of the beta-amyloid peptides by interfering with the gamma-secretase step. In mice expressing familial AD-associated mutations in APP and PSEN1, lithium reduced the levels of beta-amyloid peptides GSK3A also phosphorylates the tau protein (MAPT), the principal component of neurofibrillary tangles in AD, and suggested that inhibition of GSK3A may offer a new therapeutic approach to AD.

Host

Rabbit

Reactivity

Human

Applications

ELISA, WB

Conjugation

Unconjugated

SM22 Alpha Antibody Brand Logo
ID: BAB914475538

SM22 Alpha Antibody, Abbexa, abx430896

SM22 Alpha Antibody is a Goat Polyclonal antibody against SM22 Alpha.

Host

Goat

Reactivity

Human

Applications

P-ELISA, WB

Conjugation

Unconjugated

RELM alpha antibody Brand Logo
ID: BAB208845437

RELM alpha antibody, Genetex, GTX37350

Host

Rabbit

Reactivity

Rat

Applications

IHC-P IHC-Fr

Conjugation

Unconjugated

PGC1 alpha antibody Brand Logo
ID: BAB521351684

PGC1 alpha antibody, Genetex, GTX37356

Host

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

Conjugation

Unconjugated

CD8 alpha antibody Brand Logo
ID: BAB459170281

CD8 alpha antibody, Genetex, GTX37508

Host

Rabbit

Reactivity

Mouse

Applications

WB

Conjugation

Unconjugated

PPAR alpha Antibody
ID: BAB998694175

PPAR alpha Antibody, MedChemexpress, HY-P80871

PPAR alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PPAR alpha.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IHC-F, IHC-P, ICC/IF, ELISA

Conjugation

Non-conjugated

TNF alpha Antibody
ID: BAB436462796

TNF alpha Antibody, MedChemexpress, HY-P80914

TNF alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNF alpha.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IHC-P, ICC/IF, ELISA

Conjugation

Non-conjugated

HIF1 alpha Antibody
ID: BAB937712196

HIF1 alpha Antibody, MedChemexpress, HY-P80704

HIF1 alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to HIF1 alpha.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, ICC/IF, ELISA

Conjugation

Non-conjugated

PGC1 alpha Antibody
ID: BAB625705709

PGC1 alpha Antibody, MedChemexpress, HY-P80783

PGC1 alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PGC1 alpha.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

Conjugation

Non-conjugated

CEBP-alpha Antibody
ID: BAB943009652

CEBP-alpha Antibody, MedChemexpress, HY-P81161

CEBP-alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CEBP-alpha.

Host

Rabbit

Reactivity

Human, Rat

Applications

WB, ELISA, IHC-P, IHC-F, FC, ICC/IF

Conjugation

Non-conjugated

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