Search results for Alpha-

GSK3 alpha Antibody, Abbexa, abx033883
Glycogen synthase kinase 3-alpha (GSK3A) is a multifunctional protein serine kinase implicated in the control of several regulatory proteins including glycogen synthase and transcription factors. It also plays a role in the WNT and PI3K signaling pathways.1 Under resting conditions GSK3A and its homologs are highly phosphorylated at tyr279 in the phosphorylation loop.2 Constitutive phosphorylation of this tyrosine is important for kinase activity. Dephosphorylation of tyr279 after mitogen activation is accompanied by kinase inactivation. PKA as well as PI3K-activated PKB inactivate GSK3A by phosphorylation at ser21.3 Lysophosphatidic acid primarily utilizes a PKC-dependent pathway to modulate GSK3 and certain growth factors (e.g., PDGFB), which control GSK3 mainly through PIK3-PKB, are able to regulate GSK3 through an alternative, redundant phospholipase-C-gamma-PKC pathway.4 Alzheimer disease (AD) is associated with increased production and aggregation of amyloid-beta-40 and 42 peptides into plaques. GSK3A is required for maximal production of the beta-amyloid-40 and 42 peptides generated from the amyloid precursor protein (APP) by presenilin (PSEN1) dependent gamma-secretase cleavage.5 In vitro, lithium, a GSK3A inhibitor, blocked the production of the beta-amyloid peptides by interfering with the gamma-secretase step. In mice expressing familial AD-associated mutations in APP and PSEN1, lithium reduced the levels of beta-amyloid peptides GSK3A also phosphorylates the tau protein (MAPT), the principal component of neurofibrillary tangles in AD, and suggested that inhibition of GSK3A may offer a new therapeutic approach to AD.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated

SM22 Alpha Antibody, Abbexa, abx430896
SM22 Alpha Antibody is a Goat Polyclonal antibody against SM22 Alpha.
Host
Goat
Reactivity
Human
Applications
P-ELISA, WB
Conjugation
Unconjugated

RELM alpha antibody, Genetex, GTX37350
Host
Rabbit
Reactivity
Rat
Applications
IHC-P IHC-Fr
Conjugation
Unconjugated

PGC1 alpha antibody, Genetex, GTX37356
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugation
Unconjugated

CD8 alpha antibody, Genetex, GTX37508
Host
Rabbit
Reactivity
Mouse
Applications
WB
Conjugation
Unconjugated
PPAR alpha Antibody, MedChemexpress, HY-P80871
PPAR alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PPAR alpha.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC-F, IHC-P, ICC/IF, ELISA
Conjugation
Non-conjugated
TNF alpha Antibody, MedChemexpress, HY-P80914
TNF alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNF alpha.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC-P, ICC/IF, ELISA
Conjugation
Non-conjugated

HIF1 alpha Antibody, MedChemexpress, HY-P80704
HIF1 alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to HIF1 alpha.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ICC/IF, ELISA
Conjugation
Non-conjugated
PGC1 alpha Antibody, MedChemexpress, HY-P80783
PGC1 alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PGC1 alpha.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugation
Non-conjugated

CEBP-alpha Antibody, MedChemexpress, HY-P81161
CEBP-alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CEBP-alpha.
Host
Rabbit
Reactivity
Human, Rat
Applications
WB, ELISA, IHC-P, IHC-F, FC, ICC/IF
Conjugation
Non-conjugated
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