Search results for CD73

PerCP/Cyanine5.5 anti-mouse CD73 Antibody anti-CD73 - TY/11.8, BioLegend, 127214

TotalSeq™-B0077 anti-mouse CD73 Antibody, CD73, TY/11.8, BioLegend, 127235

TotalSeq™-C0077 anti-mouse CD73 Antibody, CD73, TY/11.8, BioLegend, 127237

CD73, Human, mAb 4G4, Hycult Biotech, HM2215

The monoclonal antibody 4G4 recognizes both membrane bound and soluble human CD73, also known as ecto-5’-nucleotidase. CD73 is a 70-kDa GPI-anchored cell surface molecule and belongs to the 5’-nucleosidase family. CD73 is useful as marker for lymphocyte differentiation. It is abundantly expressed on the vascular endothelium and at a low level on certain subpopulations of human lymphocytes. Like many glycosyl-phosphatidylinositol (GPI)-anchored molecules, it transmits potent activation signals in T cells when ligated by antibodies. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Ecto-5’-nucleotidase activity is an important mediator of the anti-inflammatory effect by converting extracellular AMP into a potent anti-inflammatory substance adenosine. CD73 has been shown to function as a co-stimulatory molecule in human T cells and to have a role in regulating lymphocyte adhesion. Triggering of CD73 on the surface of lymphocytes, but not on endothelial cells, results in the shedding of the CD73 and increased adhesion of lymphocytes to endothelium via LFA-1 clustering. Furthermore, CD73 has been implicated to mediate homing of skin-infiltrating lymphocytes in vivo. In B-cell chronic lymphocytic leukemia the expression of CD73 is decreased. Besides this, CD73 activity has been implicated as sensitive and useful indicator for mild zinc deficiency. The monoclonal antibody 4G4 causes a reduction in CD73 expression on lymphocytes, reduces enzyme activity, and inhibits the binding of lymphocytes to endothelial cells.

CD73 antibody [TY/23], Genetex, GTX14341

Anti-Hu CD73 APC, Covalab, Ref 122922

Anti-CD73 antibody [4G6E3], Abcam, AB202122

This product was changed from ascites to supernatant. Lot no's high than GR287343-13 are from Tissue Culture Supernatant

Anti-CD73 antibody [7G2], Abcam, AB54217

Anti-CD73 antibody [AD2], Abcam, AB130451

This product has switched from a hybridoma to recombinant production method on 21st September 2020. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Anti-CD73 antibody [EPR6114], Abcam, AB133582

What is this antibody validated in? Anti-CD73 antibody [EPR6114] (ab133582) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples. What is the molecular weight of CD73? Anti-CD73 [EPR6114] (ab133582) specifically detects a band for CD73 (UniProt: P21589) at a molecular weight of 63kDa. Trusted by the scientific community Anti-CD73 [EPR6114] (ab133582) was first used in a scientific publication in 2012 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-CD73 antibody [EPR6114] (ab133582) has been confirmed by Western blot testing in NT5E Knockout A431 cells. Other related products We have a range of other formats of antibody clone [EPR6114] also available for your convenience: ab133582, Carrier free - ab227113 , Carrier free - ab271895 , Alexa Fluor® 488 - ab311037 , Alexa Fluor® 647 - ab311163 , Alexa Fluor® 594 - ab311813 , Alexa Fluor® 568 - ab313096 , Alexa Fluor® 555 - ab313289 , Alexa Fluor® 750 - ab321057 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .