Monoclonal antibodies (mAbs) are highly homogeneous antibodies produced by a single B-cell clone, which recognize only one specific epitope on an antigen. The core advantages include: High specificity: binding only to a defined epitope, resulting in extremely low cross-reactivity;
Batch-to-batch consistency: derived from the same hybridoma cell line, allowing indefinite mass production with stable properties; High purity: homogeneous composition with low background noise; Excellent reproducibility: stable experimental results facilitating standardized operations.
These characteristics make monoclonal antibodies indispensable tools in scientific research, diagnostics, and biopharmaceutical applications.
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Glutamate Decarboxylase 2 (GAD2) Antibody is a Mouse Monoclonal antibody against Glutamate Decarboxylase 2 (GAD2). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. This antibody is supplied as crude ascites.
Ig Delta Chain C Region Secreted Form antibody is a Rat monoclonal against Ig Delta Chain C Region Secreted Form conjugated to PerCP / Cyanine 5.5 for use in flow cytometry applications.
Killer Cell Lectin-Like Receptor Subfamily B (KLRB) antibody is a Mouse monoclonal against Killer Cell Lectin-Like Receptor Subfamily B (KLRB) conjugated to AF450 for use in flow cytometry applications.
Myoglobin (MB), with 154-amino acid protein (about 17kDa), is a member of the globin superfamily and expression of myoglobin is highest in skeletal and cardiac muscle. Functionally, myoglobin is well accepted as an O2-storage protein in muscle, capable of releasing O2 during periods of hypoxia or anoxia. Myoglobin is also thought to buffer intracellular O2 concentration when muscle activity increases and to facilitate intracellular O2 diffusion by providing a parallel path that augments simple diffusion of dissolved O2. Furthermore, myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.
Host
Mouse
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
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