Search results for Abciximab
Abciximab Biosimilar – Anti-ITGA2B_ITGB3 mAb – Research Grade, ProteoGenix, PX-TA1104
Description of Abciximab Biosimilar - Anti-ITGA2B_ITGB3 mAb - Research Grade General information on Anti-ITGA2B_ITGB3(Homo sapiens) (Abciximab) Monoclonal Antibody Abciximab is the Fab fragment of the chimeric human mouse monoclonal antibody 7E3. Abciximab binds to human platelet glycoprotein (GP) IIb/IIIa receptors and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor and other adhesion molecules. It also binds to vitronectin (alpha v beta 3) receptors found on platelets, vascular wall endothelial cells and smooth muscle cells.
Host
Reactivity
Applications
Conjugation
Abciximab, Abbexa, abx831060
Abciximab is a monoclonal antibody biosimilar expressed in CHO cells, targeting ITGA2B/ITGB3, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. Abciximab binds to the intact platelet GPIIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa. By binding to the vitronectin receptor (also known as the αvβ3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
Host
Human, Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Abciximab Biosimilar - Research Grade, ichor.bio, ICH5056
Detects human GPIIb/IIIa. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Abciximab.
Host
CHO cells
Reactivity
Human
Applications
Conjugation
![Anti-CD41 antibody [7E3 (Abciximab)] - Rabbit IgG (Chimeric) Brand Logo](https://file.buyantibody.com/public/brand/20260608/Abcam.jpg "Click to View Anti-CD41 antibody [7E3 (Abciximab)] - Rabbit IgG (Chimeric) Product Detail")
Anti-CD41 antibody [7E3 (Abciximab)] - Rabbit IgG (Chimeric), Abcam, AB275976
This rabbit monoclonal chimeric antibody was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Host
Rabbit
Reactivity
Human
Applications
Flow Cyt
Conjugation
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