Search results for abx239939

Hypoxia Inducible Factor 1 Alpha (HIF1A) Antibody, Abbexa, abx239939

Hypoxia Inducible Factor 1 Alpha (HIF1A) Antibody is a Mouse Monoclonal antibody for the detection of HIF1a. Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256,.PMID: 7539918).