Search results for 5970

Transcription Factor p65 / NFKB3 (RELA) Antibody, Abbexa, abx326322

RELA Antibody is a Rabbit Polyclonal against RELA.

Transcription Factor p65 Phospho-Ser281 (RELA pS281) Antibody, Abbexa, abx326652

RELA (pS281) Antibody is a Rabbit Polyclonal against RELA (pS281).

Transcription Factor p65 / NFKB3 (RELA) Antibody, Abbexa, abx031446

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1) /p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Transcription Factor p65 / NFKB3 (RELA) Antibody, Abbexa, abx329031

RELA Antibody is a Rabbit Polyclonal against RELA.

Transcription Factor p65 Phospho-Thr254 (RELA pT254) Antibody, Abbexa, abx333193

RELA (pT254) Antibody is a Rabbit Polyclonal against RELA (pT254).

Transcription Factor p65 Phospho-Ser311 (RELA pS311) Antibody, Abbexa, abx333162

RELA (pS311) Antibody is a Rabbit Polyclonal against RELA (pS311).

[KO Validated] NF-kB p65/RelA Rabbit mAb, ABclonal, A19653

Phospho-NF-kB p65/RelA-S468 Rabbit mAb- ABclonal, ABclonal, AP1460

Phospho-NF-kB p65/RelA-S536 Rabbit mAb- ABclonal, ABclonal, AP1458

NFkB p65 Antibody, Abbexa, abx012273

Transcription factors of the nuclear factor kappa B (NF- kappa B)/Rel family is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. There are five family members in mammals: RelA (p65), c-Rel, RelB, NF- kappa B1 (p105/p50) and NF- kappa B2 (p100/p52). The most studied NF- kappa B complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF- kappa B with its inhibitor, I kappa B. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to I kappa B. This complex prevents nuclear translocation and activity of NF- kappa B. In response to stimuli such as cytokines, LPS, and viral infections, I kappa B is phosphorylated at critical residues. This phosphorylation induces dissociation of the I kappa B/NF- kappa B complex, allowing the free heterodimeric NF- kappa B to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the kappa B site within promoters and enhancers and functions as a transcriptional activator.