Search results for Collagen I antibody

Biotin Anti-Collagen I antibody, Abcam, AB6577

At least 11 genetically distinct gene products are collectively referred to as 'collagen types' or other proteins and proteoglycans of the extracellular matrix. In humans, collagens are composed of about 20 unique protein chains which under go various types of post-translational modifications and are ultimately assembled into a triple helix. This results in great diversity between collagen types. Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. This preparation results in a native conformation of the protein. This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Anti-Collagen I antibody [EPR7785], Abcam, AB138492

Anti-Collagen I antibody [EPR7785] (ab138492) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-Fr IHC-P and WB. Anti-Collagen I antibody [EPR7785] (ab138492) was first used in a scientific publication in 2014 and has been cited over 253 times in peer reviewed journals. It's performance in Western Blot and IHC in human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Collagen I antibody [EPR7785] (ab138492) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Collagen I antibody [EPR7785] (ab138492) has been confirmed by testing in Collagen I knockout cells. Anti-Collagen I antibody [EPR7785] (ab138492) has 34 independent reviews from customers. Anti-Collagen I antibody [EPR7785] (ab138492) specifically detects Collagen I (UniProt ID: P02452; Molecular weight: 95kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR7785 - ab215969 . Antibody clone EPR7785 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, Alexa Fluor ® 594, Alexa Fluor ® 568, Alexa Fluor ® 555, Alexa Fluor ® 750 ( ab275996 , ab280968 , ab311739 , ab313018 , ab313221 , ab321114 ). Collagen I modulates the tumor microenvironment by enhancing tissue rigidity and facilitating neoplastic cell proliferation. Additionally, it contributes to immune evasion by forming a structural barrier that impedes T-cell infiltration and activity. Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-Collagen I antibody [RM1131], Abcam, AB316222

Product Specifications Anti-Collagen I antibody [RM1131] (ab316222) is a recombinant rabbit multiclonal antibody which is comprised of multiple monoclonal antibodies targeting different epitopes and recapitulating the performance of a polyclonal. Each component clone was developed by Abcam using patented rabbit monoclonal antibody technology. Anti-Collagen I antibody [RM1131] (ab316222) is validated for use in Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP, WB in human, mouse, rat samples. Anti-Collagen I antibody [RM1131] (ab316222) specifically detects Collagen I (UniProt ID: P02452; Molecular weight: 95kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Quality and Validation Abcams high quality manufacturing and validation processes ensure Anti-Collagen I antibody [RM1131] (ab316222) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Target Information Collagen I, the most abundant collagen type in the human body, plays a significant role in oncology. It is a major component of the extracellular matrix (ECM) and contributes to the structural integrity of tissues. In cancer, Collagen I can influence tumor progression by promoting tumor cell proliferation, invasion, and metastasis through interactions with various cell surface receptors and signaling pathways. What are recombinant multiclonals? Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including: - The sensitivity of polyclonal antibodies by recognising multiple epitopes - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production View our range of recombinant multiclonal antibodies . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents .

Collagen I antibody [COL-1], Genetex, GTX26308

Anti-Collagen I antibody [COL-1], Abcam, AB6308

Anti-Collagen I antibody [COL-1] (ab6308) is a House Mouse Monoclonal antibody and is validated for use in IHC-Fr, WB. Anti-Collagen I antibody [COL-1] (ab6308) has been cited over 467 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality validation processes ensure Anti-Collagen I antibody [COL-1] (ab6308) has high sensitivity and specificity. Anti-Collagen I antibody [COL-1] (ab6308) has 33 independent reviews from customers. Anti-Collagen I antibody [COL-1] (ab6308) specifically detects Collagen I (UniProt ID: P02452; Molecular weight: 95kDa) and is sold in 50 uL selling sizes. Collagen I (COL1A1)is a major component of the extracellular matrix (ECM) and plays a significant role in cancer progression. In the tumor microenvironment, Collagen I can promote tumor growth, invasion, and metastasis by increasing tissue stiffness and facilitating cancer cell migration. Production of this antibody has been changed on 23 rd June 2016. The following lots are from ascites and are still in stock as of 23 rd June 2016 : GR210978, GR175242, GR158374. Lot numbers higher than GR210978 will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.

Anti-Collagen I antibody [EPR22209-75], Abcam, AB255809

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-Collagen I antibody [EPR22894-89], Abcam, AB260043

Anti-Collagen I antibody [EPR22894-89] (ab260043) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IP, WB in human, mouse, rat samples. Anti-Collagen I antibody [EPR22894-89] (ab260043) has been cited over 105 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-Collagen I antibody [EPR22894-89] (ab260043) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Collagen I antibody [EPR22894-89] (ab260043) specifically detects Collagen I (UniProt ID: P11087; Molecular weight: 95kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR22894-89 - ab26474. Collagen I (Collagen alpha-1(I) chain) modulates the tumor microenvironment by enhancing tissue rigidity and facilitating neoplastic cell proliferation. Additionally, it contributes to immune evasion by forming a structural barrier that impedes T-cell infiltration and activity. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-Collagen I antibody [EPR24331-53], Abcam, AB270993

Anti-Collagen I antibody [EPR24331-53] (ab270993) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP and WB. Abcam's high quality manufacturing and validation processes ensure Anti-Collagen I antibody [EPR24331-53] (ab270993) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Collagen I antibody [EPR24331-53] (ab270993) specifically detects Collagen I (UniProt ID: P11087; Molecular weight: 95kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR24331-53 - ab279711 . Antibody clone EPR24331-53 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, APC, PE, Alexa Fluor ® 568, Alexa Fluor ® 555, Alexa Fluor ® 594, Alexa Fluor ® 750 ( ab309248 , ab309367 , ab310848 , ab310918 , ab312943 , ab313153 , ab313351 , ab321535 ). Collagen I is a major component of the tumor microenvironment, influencing cancer progression by enhancing tumor stiffness, promoting metastasis and inhibiting anti-tumor immune responses. It also affects the efficacy of immunotherapies, making it a critical factor in cancer prognosis and treatment strategies. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

PE Anti-Collagen I antibody [EPR24331-53], Abcam, AB310918

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . How are conjugated primary antibodies validated? This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

APC Anti-Collagen I antibody [EPR24331-53], Abcam, AB310848

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . How are conjugated primary antibodies validated? This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. For suitable applications and species reactivity, please refer to the unconjugated version of this clone.