Neuroscience

In the field of neuroscience, antibodies are indispensable reagents for mapping neural circuits, quantifying protein pathologies and advancing the discovery of therapeutic approaches. From the localisation of ion channels and neurotransmitter receptors via immunohistochemistry (IHC) to the quantification of α-synuclein, tau and Aβ oligomers using highly sensitive enzyme-linked immunosorbent assays (ELISAs), the specificity of antibodies directly determines the accuracy of data in both basic and translational research workflows. In neurodegenerative disease research, phosphospecific and conformation-selective antibodies enable the fine-tuning of pathological aggregation staging—distinguishing soluble oligomers from fibrillar deposits in Alzheimer’s and Parkinson’s disease models. In the field of synaptic biology, antibodies targeting PSD-95, synaptophysin and AMPA receptor subunits support super-resolution imaging and colocalisation studies, which are crucial for elucidating the mechanisms of plasticity.