Search results for ER

Fibroblasts, Mouse, mAb ER-TR7, Hycult Biotech, HM1086

Monoclonal antibody ER-TR7 recognizes with an intracellular component of mouse fibroblasts. Fibroblasts are the least specialized cells in the connective-tissue family. They are dispersed in connective tissue throughout the body, where they secrete a nonrigid extracellular matrix (ECM) that is rich in type I and/or type III collagen. Conective tissue consists of glycosaminoglycans, proteoglycans and glycoproteins through which various fibres run. These fibres can be collagenous, elastic or reticular. Reticular fibres are composed from the family of collagen proteins and give tensile strength. These fibres are made by reticular fibroblasts. The activation of fibroblasts by inflammatory stimuli results in their migration, proliferation and deposition of extracellular matrix components, important features involved in both wound healing and fibrosis. The ER-TR7 antigen is a ubiquitous component of stromal (interstitial) matrix cartilage and of at least some basement membrane zones. The antigen detected is not a basement membrane component, nor any major collagen type or fibronectin. The antigen detected has a wider tissue distribution than reticulin. ER-TR7 detects an intracellular component of fibroblasts. Since ER-TR7 does not react with purified laminin, collagen types I-V, fibronectin, heparin sulfate proteoglycan, entactin or nidogen, it detects a hitherto uncharacterized antigen. The monoclonal antibody ER-TR7 can be used to study the micro-anatomy of various organs. ER-TR7 outlines the various compartments of peripheral lymphoid organs by characteristic labeling patterns (no such compartments are found in central lymphoid organs). Furthermore ER-TR7 delineates various types of connective tissue compartments in nonlymphoid organs. The antibody ER-TR7 detects reticular fibroblasts, which constitute the cellular framework of lymphoid and nonlymphoid organs and their products. ER-TR7 is useful to clearly delineated the follicles, periarteriolar lymphoid sheath and marginal zone; the major white pulp compartments. Furthermore in lymph nodes, the capsule, sinuses, follicles, paracortex and medullary cords are clearly delineated.

MGL, Mouse, mAb ER-MP23, Hycult Biotech, HM1081

The monoclonal antibody ER-MP23 specifically reacts with the macrophage galactose-specific lectin (MGL), a 38 kDa single chain surface glycoprotein. MGL is found on murine mature macrophages in the connective tissue neighboring epithelia of e.g. salivary glands, capsule of lymph nodes, thymus and various other organs. MGL is present on the surface of connective tissue macrophages and their precursor cells in bone marrow. Also, MGL is expressed in macrophage cell lines (e.g. J774-1.6, RAW309Cr.1 and WR19M.1). Expression levels of MGL are increased in mature macrophages. The antigen is co expressed with the antigen recognized by monoclonal antibody BM8 (HM1066). The monoclonal antibody ER-MP23 has been raised after immunization of rats with mouse macrophage cell lines. Blocking studies demonstrated that the monoclonal antibody ER-MP23 is able to block mouse MGL.

SIGN-R1 antibody [ER-TR9], Genetex, GTX39135

Anti-Ly6c antibody [ER-MP20], Abcam, AB54223

This product should be stored undiluted. Shelf life - 18 months Studies show that clone ER-MP20 can be used in conjunction with clone ER-MP12 in two colour flow cytometric analysis, to identify different stages of myeloid progenitor cells in mouse bone marrow. Product Specifications Anti-Ly6c antibody [ER-MP20] (ab54223) is a rat monoclonal antibody and is validated for use in Flow Cyt, IHC-Fr in mouse samples. Anti-Ly6c antibody [ER-MP20] (ab54223) specifically detects Ly6c (UniProt ID: P0CW03; Molecular weight: 9kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-Ly6c antibody [ER-MP20] (ab54223) has high sensitivity and specificity. Anti-Ly6c antibody [ER-MP20] (ab54223) has been cited over 13 times in peer reviewed journals and is trusted by the scientific community. Related Products Conjugation-ready, carrier free format available for antibody clone ER-MP20 - ab236269 .

Anti-Calnexin antibody - ER Marker, Abcam, AB22595

Anti-Calnexin antibody - ER Marker (ab22595) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IP, WB in human samples. Anti-Calnexin antibody - ER Marker (ab22595) has been cited over 482 times in peer reviewed journals, has been used for calnexin staining and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Calnexin antibody - ER Marker (ab22595) has high sensitivity and specificity. The specificity of Anti-Calnexin antibody - ER Marker (ab22595) has been confirmed by testing in knockout samples. Anti-Calnexin antibody - ER Marker (ab22595) has 28 independent reviews from customers. Anti-Calnexin antibody - ER Marker (ab22595) specifically detects Calnexin (UniProt ID: P27824; Molecular weight: 65kDa) and is sold in 100 µg selling sizes. Calnexin, an endoplasmic reticulum (ER) chaperone protein, plays a crucial role in oncology by influencing the immune response to tumors and cancer cell behavior. It can impair antitumor immunity by inhibiting T-cell infiltration and enhancing PD-1 expression on T cells, which suppresses their activity. Additionally, aberrant O-glycosylation of calnexin is linked to increased cancer cell migration and adhesion. Explore our range of organelle-specific antibodies and dyes and discover why our reagents are deeply trusted by cell biologists.

Anti-Calreticulin antibody - ER Marker, Abcam, AB2907

Anti-Calreticulin antibody - ER Marker (ab2907) is a rabbit polyclonal antibody and is validated for use in ICC/IF, WB in human, mouse, rat samples. Anti-Calreticulin antibody - ER Marker (ab2907) has been cited over 256 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Calreticulin antibody - ER Marker (ab2907) has high sensitivity and specificity. Anti-Calreticulin antibody - ER Marker (ab2907) has 16 independent reviews from customers. Anti-Calreticulin antibody - ER Marker (ab2907) specifically detects Calreticulin (UniProt ID: P27797; Molecular weight: 46kDa) and is sold in 100 µL selling sizes. Calreticulin (CALR, HACBP) is a multifunctional protein involved in protein folding and calcium homeostasis within the endoplasmic reticulum. In oncology, it plays a crucial role in immunogenic cell death by acting as a signal for immune cells to target and destroy cancer cells. Calreticulin (CALR, HACBP) is also implicated in tumor progression and metastasis due to its role in cell adhesion and migration. As a result, it is being explored as a potential therapeutic target for cancer treatment.

Ly6c antibody [ER-MP20] (PE), Genetex, GTX42957

Ly6c antibody [ER-MP20] (Biotin), Genetex, GTX43843

Anti-ESR2/ER-beta Antibody (R2J45), AntibodySystem, RHJ32701

SIGN-R1, Mouse, mAb ER-TR9, Hycult Biotech, HM1080-1ML

The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,- a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes , particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages.