Search results for DNA polymerase iota

DNA Polymerase Iota (POLI) Antibody, Abbexa, abx028115

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Anti-DNA Polymerase iota antibody, Abcam, AB228783

Anti-DNA Polymerase iota antibody, Abcam, AB264193

DNA Polymerase Iota (POLI) Antibody, Abbexa, abx001585

POLI Antibody is a Rabbit Polyclonal antibody against POLI. Mammalian Polymerase iota (POL ι or POLI) owns an unusual combination of properties: it is stimulated by Mn2+ ions, can bypass some DNA lesions and misincorporates "G" opposite template "T" more frequently than incorporates the correct "A". [PMID:21304950] It also was shown to possess dRP lyase activity. In addition, POLI is much more efficient in the presence of Mn2+ in comparison to Mg2+. [PMID: 17609217]. It has been proposed that POLI involves in immunoglobulin somatic hypermutation (SHM), bypass of deaminated cytosines, several adducts of the purine bases. DNA strand crosslinks and is involved in DNA repair under oxidative stress. [PMID:15199127].

DNA Polymerase Iota (POLI) Antibody (FITC), Abbexa, abx335404

POLI Antibody (FITC) is a Rabbit Polyclonal against POLI.

DNA Polymerase Iota (POLI) Antibody (Biotin), Abbexa, abx335405

POLI Antibody (Biotin) is a Rabbit Polyclonal against POLI.

Anti-DNA Polymerase iota antibody [OTI1H9], Abcam, AB157244

The clone number has been updated from 1H9 to OTI1H9, both clone numbers name the same clone.

DNA Polymerase Iota (POLI) Antibody (HRP), Abbexa, abx335403

POLI Antibody (HRP) is a Rabbit Polyclonal against POLI.

Human DNA Polymerase Iota (POLI) ELISA Kit, Abbexa, abx382346

Human DNA Polymerase Iota (POLI) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human POLI concentrations in tissue homogenates, cell lysates and other biological fluids.

Mouse DNA polymerase iota (POLI) ELISA Kit, Abbexa, abx539525

Mouse DNA polymerase iota (POLI) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse DNA polymerase iota concentrations in tissue homogenates, cell lysates and other biological fluids.