Search results for Collagen IV Antibody

Anti-Collagen IV antibody, Abcam, AB19808

What is this antibody validated in? Anti-Collagen IV antibody (ab19808) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Mouse samples. Trusted by the scientific community Anti-Collagen IV (ab19808) was first used in a scientific publication in 2005 and has been cited over 160 times in peer-reviewed journals. Reviewed by scientists Anti-Collagen IV (ab19808) has over 20 independent reviews from customers.

Anti-Collagen IV antibody, Abcam, AB217147

Anti-Collagen IV antibody, Abcam, AB235296

Anti-Collagen IV antibody, Abcam, AB6586

Anti-Collagen IV antibody (ab6586) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC/IF, IF, IHC-FoFr, IHC-Fr, IHC-FrFl, Anti-Collagen IV antibody (ab6586) was first used in a scientific publication in 2004 and has been cited over 920 times in peer reviewed journals. It's performance in IHC and Western Blot in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Collagen IV antibody (ab6586) has high sensitivity and specificity. Anti-Collagen IV antibody (ab6586) has 120 independent reviews from customers. Anti-Collagen IV antibody (ab6586) specifically detects Collagen IV (UniProt ID: P02462; Molecular weight: ~160kDa) and is sold in 100 µg selling sizes. Collagen IV is a key component of the extracellular matrix in tumors, contributing to tissue stiffness and promoting cancer cell invasion. It plays a significant role in tumor progression and metastasis, influencing the behaviour of cancer cells.

Biotin Anti-Collagen IV antibody, Abcam, AB6581

At least 11 genetically distinct gene products are collectively referred to as 'collagen types' or other proteins and proteoglycans of the extracellular matrix. In humans, collagens are composed of about 20 unique protein chains which under go various types of post-translational modifications and are ultimately assembled into a triple helix. This results in great diversity between collagen types. Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. This preparation results in a native conformation of the protein. These antibodies are well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Collagen IV antibody [COL4/4241R], Genetex, GTX02748

Collagen IV antibody [rCOL4/4742], Genetex, GTX02749

Anti-Collagen IV antibody [1043], Abcam, AB86042

In IHC, recognizes the extracellular – basement membranes. We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 27 th October 2017. The following lots are still unpurified and still in stock as of 27 th October 2017- GR275641-7, GR275641-13, and GR275641-14. Lot numbers other than GR275641-7, GR275641-13, and GR275641-14 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.

Anti-Collagen IV antibody [EPR20966], Abcam, AB214417

What is this antibody validated in? Anti-Collagen IV antibody [EPR20966] (ab214417) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples. What is the molecular weight of Collagen IV? Anti-Collagen IV [EPR20966] (ab214417) specifically detects a band for Collagen IV (UniProt: P02462) at a molecular weight of 161kDa. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Collagen IV antibody [EPR20966] (ab214417) has been confirmed by Western blot testing in COL4A1 Knockout HeLa cell line, ab255379 . Other related products We have a range of other formats of antibody clone [EPR20966] also available for your convenience: ab214417, Carrier free - ab226485 , PE - ab317886 , APC - ab317923 , Alexa Fluor® 488 - ab317963 , Alexa Fluor® 594 - ab318004 , Alexa Fluor® 555 - ab318046 , Alexa Fluor® 647 - ab318088 , Alexa Fluor® 750 - ab321376 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Anti-Collagen IV antibody [RM1065], Abcam, AB315250

What are recombinant multiclonals? Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including: - The sensitivity of polyclonal antibodies by recognising multiple epitopes - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production View our range of recombinant multiclonal antibodies . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents .